Hydrogen peroxide production by epidermal dual oxidase 1 regulates nociceptive sensory signals
Keratinocytes of the mammalian skin provide not only mechanical protection for the tissues, but also transmit mechanical, chemical, and thermal stimuli from the external environment to the sensory nerve terminals.Sensory nerve fibers penetrate the epidermal basement membrane and function in the tight intercellular space among keratinocytes.Here we